Creating space for future health
We use cutting edge science and collaborative clinical practice, to find, develop and test effective treatments at speed
Encouraging leadership from everyone to achieve the core aims of our programme
Preparing the ground for future pandemic response through the creation of global outbreak infrastructure and governance approaches
Vitamin D insufficiency in COVID-19 and influenza A
Vitamin D deficiency/insufficiency was present in the majority of hospitalised patients with Covid-19 (ISARIC4C study) and influenza A (MOSAIC study, 2009-10 H1N1 pandemic), correlated with severity and persisted in non-selected critical illness survivors (prior to Covid-19 pandemic) at...
MoreSuppression of virus replication in COVID-19 patients
Human Leukocyte Antigen E (HLA-E) restricted T-cells could contribute to the control of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection alongside classical T cells. According to this study, ISARIC4C described five peptides from SARS-CoV-2 that elicited HLA-E-restricted...
MoreViral spike variants evading antibody-mediated immunity
We showed that the N439K viral mutation has enhanced binding affinity tothe ACE2 receptor and that this variant cause infections with similarclinical outcomes compared to the wild type. This mutation is resistantagainst neutralising monoclonal antibodies and from polyclonal...
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